Improving Response Inhibition in Parkinson’s Disease with Atomoxetine
نویسندگان
چکیده
منابع مشابه
Improving Response Inhibition in Parkinson’s Disease with Atomoxetine
BACKGROUND Dopaminergic drugs remain the mainstay of Parkinson's disease therapy but often fail to improve cognitive problems such as impulsivity. This may be due to the loss of other neurotransmitters, including noradrenaline, which is linked to impulsivity and response inhibition. We therefore examined the effect of the selective noradrenaline reuptake inhibitor atomoxetine on response inhibi...
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Parkinson's disease impairs the inhibition of responses, and whilst impulsivity is mild for some patients, severe impulse control disorders affect ∼10% of cases. Based on preclinical models we proposed that noradrenergic denervation contributes to the impairment of response inhibition, via changes in the prefrontal cortex and its subcortical connections. Previous work in Parkinson's disease fou...
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ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 2015
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2014.01.024